Moreover, this condition is characterized by a decline in immune competence and reduced capacity to generate tolerance to innocuous antigens ( 2). These age-associated immune changes are known as immunosenescence and promote a pro-inflammatory profile called inflammaging ( 1). Furthermore, in senescent mice, SDP supplementation augmented Il-4 and Il-10 expression in both tissues ( p < 0.05).Ĭonclusion: SDP reduces the mucosal inflammation associated with aging, improving vaccine protection in senescent mice.ĭuring senescence, there is increased activation of the immune system that impairs pathogen-specific responses. Moreover, after the lethal challenge, aged mice showed higher expression levels of pro-inflammatory cytokines ( Il-6, Tnf-α, Ifn-γ, and Il-1β) in jejunal and ( Tnf-α, and Il-1β) in lung tissues ( p < 0.05), which were reduced by SDP supplementation ( p < 0.05). After the lethal shock, all immunized aged mice that were supplemented with SDP survived, in contrast to only 66% of those fed the control feed ( p < 0.05). Results: Immunization increased anti-SEB IgA in intestinal and bronchoalveolar fluid ( p < 0.05). Fifteen days after the last dose, a lethal shock was induced by intraperitoneal administration of SEB and LPS. The mice received nasal doses of 2.5 μg of Staphylococcus aureus enterotoxin B (SEB) or vehicle every 15 days (i.e., 3 times). Methods: Experiments were performed in 2-month-old and 6-month-old male SAMP8 mice fed control or SDP (8%) feeds for 4 months. We aimed to determine if the anti-inflammatory properties of SDP improve the efficiency of immunization in senescent animals. Dietary supplementation with spray-dried porcine plasma (SDP) exerts anti-inflammatory effects in different mucosal areas. 1Departament de Bioquímica i Fisiologia, Facultat de Farmàcia i Ciències de l’Alimentació and Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB), Universitat de Barcelona (UB), Barcelona, Spainīackground: Senescence is characterized by an aggravated inflammatory state that reduces vaccine responsiveness.Lluïsa Miró 1 †, Cristina Rosell-Cardona 1 †, Concepció Amat 1, Javier Polo 2, Miquel Moretó 1 and Anna Pérez-Bosque 1 *
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